Which of the following is an example of an NNRTI?

The choice of efavirenz as an example of a non-nucleoside reverse transcriptase inhibitor (NNRTI) is appropriate because it specifically targets the HIV reverse transcriptase enzyme in a manner distinct from nucleoside reverse transcriptase inhibitors (NRTIs). NNRTIs bind to a specific site on the enzyme, inducing conformational changes that inhibit its function, effectively preventing the conversion of viral RNA into DNA, which is a crucial step in the HIV replication cycle.

Efavirenz is widely used as part of antiretroviral therapy for HIV infection due to its efficacy and once-daily dosing. Its role as an NNRTI places it in a different class of medications compared to those like tenofovir and zidovudine, which are NRTIs that compete with nucleotides for incorporation into viral DNA, or atazanavir, which is a protease inhibitor that interferes with viral protein processing. Understanding these distinctions helps in recognizing the various therapeutic strategies in managing HIV.