Which adverse effect is associated with many antiviral drugs?

Nephrotoxicity is recognized as a significant adverse effect associated with many antiviral drugs, particularly those used to treat viral infections such as HIV and hepatitis. Certain antivirals, including the nucleoside reverse transcriptase inhibitors (NRTIs) and some antiviral agents like acyclovir and tenofovir, can impair kidney function. This is particularly concerning because renal impairment may alter the pharmacokinetics of the drugs, leading to increased serum levels, which can enhance the risk of toxicity.

Patients receiving these medications may require routine monitoring of renal function to prevent potential complications related to nephrotoxicity. Managing hydration and adjusting dosages based on renal function are critical steps that healthcare professionals may take to mitigate this risk. Understanding the nephrotoxic potential of certain antivirals is essential for clinicians to provide comprehensive care and monitor for signs of renal impairment in patients undergoing antiviral therapy.