What therapy is typically first-line treatment for uncomplicated influenza?

The first-line treatment for uncomplicated influenza is antiviral therapy, specifically the use of medications like oseltamivir. This antiviral works by inhibiting the neuraminidase enzyme, which is crucial for the influenza virus's ability to replicate and spread in the respiratory tract. Early intervention with antiviral therapy can help reduce the duration of symptoms, limit the severity of the illness, and may lower the risk of complications.

Other treatment options listed, such as IV hydration therapy, are generally supportive measures used for more severe cases or situations where patients are dehydrated. High-dose vitamin C therapy does not have strong evidence supporting its effectiveness as a treatment for influenza and is not used as a standard therapy. Intranasal corticosteroids may help alleviate nasal symptoms but do not directly address the viral infection or its replication. Therefore, antiviral medications like oseltamivir remain the cornerstone of treatment for uncomplicated influenza.