In which clients is the use of cidofovir contraindicated?

Cidofovir is an antiviral medication primarily used in the treatment of certain viral infections, including cytomegalovirus (CMV) retinitis in patients with AIDS. One of the key considerations in its use is its nephrotoxicity, which means it can have harmful effects on the kidneys.

In individuals with renal impairment, the use of cidofovir can significantly exacerbate existing kidney issues, leading to potential acute renal failure. Cidofovir requires careful dosage adjustments in those with compromised renal function, and in many cases, it is recommended to avoid its use altogether if renal impairment is severe. This is crucial to prevent further deterioration of kidney health and manage the risk of serious side effects.

While considering other health factors, such as liver disease, respiratory issues, and hypertension, these do not directly contraindicate the use of cidofovir as strongly as renal impairment does. Individuals with liver disease may still be monitored carefully if cidofovir is considered, and respiratory or hypertension concerns may not present the same level of risk as renal issues in the context of cidofovir therapy. Thus, the clear contraindication for cidofovir lies with clients who have renal impairment, making the answer appropriate.