How is Amphotericin B administered?

Amphotericin B is primarily administered intravenously because it is a poorly water-soluble agent that is used to treat serious fungal infections. The intravenous route allows for the drug to be delivered directly into the bloodstream, ensuring that it reaches effective concentrations in systemic circulation to target severe and life-threatening infections, such as cryptococcal meningitis or systemic candidiasis.

While other routes of administration exist for different types of medications, Amphotericin B's formulation and pharmacokinetics make IV administration the most effective method for achieving the desired therapeutic effect. Oral administration would not provide adequate bioavailability, as the drug could be degraded in the gastrointestinal tract before it enters systemic circulation. Subcutaneous and topical routes are similarly unsuitable for Amphotericin B due to the need for high systemic concentrations to combat invasive fungal infections.